First-line pharmacotherapy for Trichomoniasis is which agent?

• A. Metronidazole
• B. Azithromycin
• C. Ceftriaxone
• D. Doxycycline

Answer: (A)

Metronidazole is the first-line therapy for Trichomonas infection because it is a nitroimidazole with strong activity against anaerobic protozoa like Trichomonas vaginalis. When activated inside the parasite, it damages its DNA, effectively clearing the infection. The recommended regimens include a single 2-gram oral dose or 500 mg taken twice daily for seven days. If metronidazole can’t be used, tinidazole is an alternative. Avoid alcohol during treatment and for about 24 hours after to prevent a disulfiram-like reaction. The other agents listed don’t treat Trichomonas infections; they target bacteria (such as gonorrhea or chlamydia) and are not first-line for this protozoal infection.