G6PD deficiency is most prevalent in which group?

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Multiple Choice

G6PD deficiency is most prevalent in which group?

Explanation:
G6PD deficiency is inherited in an X-linked recessive pattern, so males are affected more often since they have a single X chromosome. In populations of African descent, the G6PD A- variant is common, which increases overall prevalence among African-American males. Females typically need two defective X chromosomes to show the condition (or have skewed X-inactivation), so they are less frequently affected and more often just carriers. Because of both the inheritance pattern and higher variant frequency in this population, African-American males have the highest prevalence among the groups listed.

G6PD deficiency is inherited in an X-linked recessive pattern, so males are affected more often since they have a single X chromosome. In populations of African descent, the G6PD A- variant is common, which increases overall prevalence among African-American males. Females typically need two defective X chromosomes to show the condition (or have skewed X-inactivation), so they are less frequently affected and more often just carriers. Because of both the inheritance pattern and higher variant frequency in this population, African-American males have the highest prevalence among the groups listed.

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