In G6PD deficiency, which preventive measure is recommended?

• A. Avoid vaccines
• B. Regular blood transfusions
• C. Increase iron intake
• D. Avoid triggers such as fava beans and naphthalene

Answer: (D)

G6PD deficiency makes red blood cells vulnerable to oxidative stress because they can’t generate enough NADPH to keep glutathione in the reduced form. Exposures that create oxidative stress can trigger hemolysis, so the best preventive measure is to avoid known oxidant triggers like fava beans and naphthalene (the latter found in mothballs and some solvents). By staying away from these triggers, you reduce the chance of hemolytic episodes. Vaccines are not a trigger and are generally safe and recommended; regular blood transfusions address established anemia rather than prevention; iron supplementation helps only if there’s true iron deficiency and won’t prevent oxidative hemolysis.