In multiple sclerosis, which CSF finding supports the diagnosis?

• A. Elevated glucose
• B. Oligoclonal bands
• C. Neutrophilia
• D. No abnormality

Answer: (B)

Intrathecal IgG synthesis shown by oligoclonal bands is a classic CSF finding that supports multiple sclerosis. Oligoclonal bands are discrete IgG bands seen on CSF electrophoresis that are present in the CSF but not in the serum, indicating antibody production within the central nervous system. This pattern is seen in the majority of MS patients and, when integrated with typical clinical features and MRI findings of demyelinating lesions, strengthens the diagnosis.

Elevated glucose is not characteristic of MS; CSF glucose is usually normal. Neutrophilia points toward acute bacterial infection rather than MS. No abnormality would be unlikely given the common CSF changes in MS.