In Samter's triad, which medication class should be avoided?

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Multiple Choice

In Samter's triad, which medication class should be avoided?

Explanation:
Samter's triad is aspirin-exacerbated respiratory disease, where NSAIDs and aspirin trigger symptoms by inhibiting COX-1 and shunting arachidonic acid toward the 5-lipoxygenase pathway, leading to increased leukotriene production that promotes bronchospasm and worsens nasal polyps. Because of this mechanism, avoiding NSAIDs and aspirin is essential. Other options aren’t inherently contraindicated: intranasal corticosteroids help reduce nasal inflammation and polyps, montelukast blocks leukotriene receptors and can aid control of airway reactivity, and antihistamines address histamine-related allergy symptoms but don’t drive the problem in Samter’s triad.

Samter's triad is aspirin-exacerbated respiratory disease, where NSAIDs and aspirin trigger symptoms by inhibiting COX-1 and shunting arachidonic acid toward the 5-lipoxygenase pathway, leading to increased leukotriene production that promotes bronchospasm and worsens nasal polyps. Because of this mechanism, avoiding NSAIDs and aspirin is essential. Other options aren’t inherently contraindicated: intranasal corticosteroids help reduce nasal inflammation and polyps, montelukast blocks leukotriene receptors and can aid control of airway reactivity, and antihistamines address histamine-related allergy symptoms but don’t drive the problem in Samter’s triad.

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