Laboratory findings in Hemophilia B include which of the following?

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Study for the PANCE Precision Exam. Improve with flashcards and multiple choice questions, each question has hints and explanations. Get ready for your exam!

Multiple Choice

Laboratory findings in Hemophilia B include which of the following?

Explanation:
Hemophilia B is caused by a deficiency of factor IX, which is part of the intrinsic coagulation pathway. The intrinsic pathway’s activity is reflected by the activated partial thromboplastin time (PTT), so a factor IX deficiency prolongs the PTT. The prothrombin time (PT) assesses the extrinsic pathway and remains normal because factor VII and the extrinsic pathway aren’t affected in hemophilia B. That’s why the typical lab picture is decreased factor IX with a prolonged PTT. A prolonged PT would point to an extrinsic issue, and a decreased factor VIII would indicate Hemophilia A, while a normal PTT would not align with an intrinsic pathway deficiency.

Hemophilia B is caused by a deficiency of factor IX, which is part of the intrinsic coagulation pathway. The intrinsic pathway’s activity is reflected by the activated partial thromboplastin time (PTT), so a factor IX deficiency prolongs the PTT. The prothrombin time (PT) assesses the extrinsic pathway and remains normal because factor VII and the extrinsic pathway aren’t affected in hemophilia B. That’s why the typical lab picture is decreased factor IX with a prolonged PTT. A prolonged PT would point to an extrinsic issue, and a decreased factor VIII would indicate Hemophilia A, while a normal PTT would not align with an intrinsic pathway deficiency.

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