Paget disease often shows skull enlargement and what laboratory finding?

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Multiple Choice

Paget disease often shows skull enlargement and what laboratory finding?

Explanation:
Paget disease is a disorder of bone remodeling with increased osteoclast activity followed by excessive osteoblastic bone formation, leading to thick, disorganized bone and often skull enlargement. The pivotal lab finding reflects this high bone turnover: alkaline phosphatase is markedly elevated because osteoblasts ramp up producing new bone. Calcium and phosphate levels usually remain normal, since serum calcium is tightly regulated and the disease does not typically cause hypercalcemia. A decreased alkaline phosphatase would not fit the active bone formation. So, the hallmark lab finding is a markedly elevated alkaline phosphatase.

Paget disease is a disorder of bone remodeling with increased osteoclast activity followed by excessive osteoblastic bone formation, leading to thick, disorganized bone and often skull enlargement. The pivotal lab finding reflects this high bone turnover: alkaline phosphatase is markedly elevated because osteoblasts ramp up producing new bone. Calcium and phosphate levels usually remain normal, since serum calcium is tightly regulated and the disease does not typically cause hypercalcemia. A decreased alkaline phosphatase would not fit the active bone formation. So, the hallmark lab finding is a markedly elevated alkaline phosphatase.

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