Which anti-androgen used for hirsutism in PCOS is teratogenic and must be used with concurrent OCPs?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $25.99Unlock all

Study for the PANCE Precision Exam. Improve with flashcards and multiple choice questions, each question has hints and explanations. Get ready for your exam!

Multiple Choice

Which anti-androgen used for hirsutism in PCOS is teratogenic and must be used with concurrent OCPs?

Explanation:
Blocking androgen effects in hair follicles is the key approach for hirsutism in PCOS. Spironolactone serves as a steroidal antiandrogen, binding to androgen receptors and reducing the hair-growth response to circulating androgens. Because it can cause birth defects, it is teratogenic, so it must be used only with reliable contraception. In practice, it’s paired with a combined oral contraceptive to prevent pregnancy while the drug works. Other antiandrogens carry safety concerns or aren’t the standard first-line choice for PCOS-related hirsutism, making spironolactone the best fit for this scenario.

Blocking androgen effects in hair follicles is the key approach for hirsutism in PCOS. Spironolactone serves as a steroidal antiandrogen, binding to androgen receptors and reducing the hair-growth response to circulating androgens. Because it can cause birth defects, it is teratogenic, so it must be used only with reliable contraception. In practice, it’s paired with a combined oral contraceptive to prevent pregnancy while the drug works. Other antiandrogens carry safety concerns or aren’t the standard first-line choice for PCOS-related hirsutism, making spironolactone the best fit for this scenario.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy