Which histologic type is most commonly associated with bladder cancer?

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Study for the PANCE Precision Exam. Improve with flashcards and multiple choice questions, each question has hints and explanations. Get ready for your exam!

Multiple Choice

Which histologic type is most commonly associated with bladder cancer?

Explanation:
Bladder cancer most commonly arises from the urothelium, the transitional epithelium lining the bladder, so the typical histology is transitional cell carcinoma (urothelial carcinoma). This type makes up the vast majority of bladder cancers—roughly the majority in many populations. Other histologies occur much less often: adenocarcinoma is less common and can be related to urachal remnants, squamous cell carcinoma is linked to chronic irritation or infection (such as schistosomiasis or long-standing cystitis), and small cell carcinoma is rare. Thus, transitional cell carcinoma best fits the common pattern of bladder malignancy.

Bladder cancer most commonly arises from the urothelium, the transitional epithelium lining the bladder, so the typical histology is transitional cell carcinoma (urothelial carcinoma). This type makes up the vast majority of bladder cancers—roughly the majority in many populations. Other histologies occur much less often: adenocarcinoma is less common and can be related to urachal remnants, squamous cell carcinoma is linked to chronic irritation or infection (such as schistosomiasis or long-standing cystitis), and small cell carcinoma is rare. Thus, transitional cell carcinoma best fits the common pattern of bladder malignancy.

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