Which nutrient has been suggested to slow progression of age-related macular degeneration?

• A. Vitamin C
• B. Vitamin E
• C. Zinc
• D. Calcium

Answer: (C)

Oxidative stress in the retina plays a role in advancing age-related macular degeneration, and trial evidence shows that a high-dose zinc-containing formulation, given with antioxidants, can slow progression in people with intermediate AMD. Zinc supports antioxidant defense by acting as a cofactor for enzymes that protect retinal cells and help maintain the health of the retinal pigment epithelium. The most consistent AMD-progression benefit from the AREDS studies came from including zinc as part of that supplement combination (along with vitamins C and E and copper). Calcium isn’t linked to slowing AMD progression, and vitamins C and E alone haven’t shown the same proven effect outside of the specific AREDS combination. Therefore, zinc is the nutrient most associated with slowing AMD progression.