Which treatment is considered effective when started early in Guillain-Barré syndrome?

• A. Plasmapheresis
• B. Prednisone
• C. Antibiotics
• D. Antivirals

Answer: (A)

Guillain-Barré syndrome is an autoimmune attack on the peripheral nerves, and starting immunomodulatory therapy early can meaningfully improve outcomes. Plasmapheresis, or plasma exchange, works by removing circulating autoantibodies and inflammatory mediators that drive demyelination and nerve injury. When begun early in the course, it can shorten the time to recovery and decrease the risk of respiratory failure requiring ventilation. Corticosteroids like prednisone have not shown benefit in altering the disease course, so they are not effective for this condition. Antibiotics or antivirals do not address the autoimmune process of Guillain-Barré syndrome and thus are not used as a treatment for the syndrome itself.