Which tumor is listed as an ectopic ACTH-secreting source in Cushing syndrome?

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Study for the PANCE Precision Exam. Improve with flashcards and multiple choice questions, each question has hints and explanations. Get ready for your exam!

Multiple Choice

Which tumor is listed as an ectopic ACTH-secreting source in Cushing syndrome?

Explanation:
Ectopic ACTH production occurs when a nonpituitary tumor independently secretes ACTH, driving the adrenal cortex to excess cortisol and causing Cushing syndrome. The classic source is a neuroendocrine tumor of the lung, particularly small cell carcinoma, because these tumors autonomously produce ACTH regardless of hypothalamic-pituitary signals. This leads to elevated ACTH and cortisol with features like hypertension, hyperglycemia, hypokalemia, and metabolic alkalosis, and typically poor suppression on high-dose dexamethasone testing. The other tumors listed do not commonly secrete ACTH ectopically, so they aren’t the usual sources of ectopic ACTH syndrome.

Ectopic ACTH production occurs when a nonpituitary tumor independently secretes ACTH, driving the adrenal cortex to excess cortisol and causing Cushing syndrome. The classic source is a neuroendocrine tumor of the lung, particularly small cell carcinoma, because these tumors autonomously produce ACTH regardless of hypothalamic-pituitary signals. This leads to elevated ACTH and cortisol with features like hypertension, hyperglycemia, hypokalemia, and metabolic alkalosis, and typically poor suppression on high-dose dexamethasone testing. The other tumors listed do not commonly secrete ACTH ectopically, so they aren’t the usual sources of ectopic ACTH syndrome.

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